GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs11880706 | 1 | rs59907625 | chr19:6079598 | RFX2 | chr19:5993176-6110664:- | 0.37 | 3.91 | 0.000107 | Bipolar disorder and schizophrenia |
| THCA | cis | rs599083 | 1 | rs599083 | chr11:68192346 | LOC645332 | chr11:67559240-67572807:- | 0.16 | 3.5 | 0.000514 | Bone mineral density (spine) |
| THCA | cis | rs1978968 | 1 | rs5992135 | chr22:18447114 | MICAL3 | chr22:18270418-18507325:- | -0.2 | -4.13 | 4.32E-5 | Presence of antiphospholipid antibodies |
| THCA | cis | rs12435908 | 1 | rs59921977 | chr14:66018659 | LOC645431 | chr14:65877313-65879335:- | -0.6 | -7.55 | 2.21E-13 | Ischemic stroke |
| THCA | cis | rs8078723 | 1 | rs59925331 | chr17:38169273 | GSDMA | chr17:38119226-38134019:+ | -0.31 | -7.24 | 1.75E-12 | Neutrophil count;White blood cell count;C-reactive protein and white blood cell count |
| THCA | cis | rs1978968 | 1 | rs5992917 | chr22:18443699 | MICAL3 | chr22:18270418-18507325:- | -0.21 | -4.27 | 2.33E-5 | Presence of antiphospholipid antibodies |
| THCA | cis | rs1978968 | 1 | rs5992919 | chr22:18443855 | MICAL3 | chr22:18270418-18507325:- | -0.21 | -4.27 | 2.33E-5 | Presence of antiphospholipid antibodies |
| THCA | cis | rs1978968 | 1 | rs5992921 | chr22:18445263 | MICAL3 | chr22:18270418-18507325:- | -0.19 | -3.96 | 8.62E-5 | Presence of antiphospholipid antibodies |
| THCA | cis | rs1978968 | 1 | rs5992922 | chr22:18445287 | MICAL3 | chr22:18270418-18507325:- | -0.19 | -3.96 | 8.62E-5 | Presence of antiphospholipid antibodies |
| THCA | cis | rs1978968 | 1 | rs5992926 | chr22:18449876 | MICAL3 | chr22:18270418-18507325:- | -0.2 | -3.98 | 7.86E-5 | Presence of antiphospholipid antibodies |
| THCA | cis | rs1978968 | 1 | rs5992928 | chr22:18451438 | MICAL3 | chr22:18270418-18507325:- | -0.2 | -3.97 | 8.38E-5 | Presence of antiphospholipid antibodies |
| THCA | cis | rs60843830 | 1 | rs59937473 | chr2:271797 | SH3YL1 | chr2:218138-264810:- | -0.93 | -25.8 | 1.3E-92 | Spherical equivalent (joint main effects and education interaction) |
| THCA | cis | rs5994434 | 1 | rs5994434 | chr22:32229649 | SFI1 | chr22:31892261-32014533:+ | -0.24 | -4.58 | 5.87E-6 | Intelligence |
| THCA | cis | rs4888671 | 1 | rs59945106 | chr16:77780154 | NUDT7 | chr16:77756411-77776153:+ | 0.36 | 4.99 | 8.33E-7 | Obesity-related traits |
| THCA | cis | rs2241437 | 1 | rs59947468 | chr2:86289436 | LOC90784 | chr2:86247339-86250991:- | -0.61 | -6.49 | 2.17E-10 | Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) |